Hypoxia suffocates histone demethylases to change gene expression: a metabolic control of histone methylation
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منابع مشابه
Hypoxia suffocates histone demethylases to change gene expression: a metabolic control of histone methylation
Hypoxia affects various physiological and pathophyological processes. Hypoxia changes the expression of hypoxiaresponsive genes through two main pathways. First, hypoxia activates transcription factors (TF) such as Hypoxia-inducible Factor (HIF). Second, hypoxia decreases the activity of Jumonji C domain-containing histone demethylases (JMJDs) that require O2 and α-Ketoglutarate (α-KG) as subst...
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ژورنال
عنوان ژورنال: BMB Reports
سال: 2017
ISSN: 1976-670X
DOI: 10.5483/bmbrep.2017.50.11.200